Die schöne PRANA


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Eröffnet am:28.11.13 09:43von: buranAnzahl Beiträge:108
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805 Postings, 4275 Tage vstrecker2,01 +5,78%

 
  
    #51
10.06.14 16:01

805 Postings, 4275 Tage vstrecker2,38 Mittlerweile und in FWB heute +15% :-)

 
  
    #52
09.07.14 12:11
Ziemlich nett!  

805 Postings, 4275 Tage vstreckerYES! +10% heute!

 
  
    #53
09.07.14 16:35
Prana ist nur geil... Die geht gleich mal durch die Decke  

828 Postings, 4864 Tage Toller HechtSieht gut aus!

 
  
    #54
14.07.14 11:11
Denke hier geht noch einiges die nächsten Wochen m.M.n!  

805 Postings, 4275 Tage vstreckerPre Market +25%

 
  
    #56
17.07.14 13:49
Das sieht ziemlich gut aus. Mal sehen, ob das hält und die Leute verstehen, dass das Stoppen der Gehirnschrumpfung ein positiver Wahnsinn ist :-)  

805 Postings, 4275 Tage vstreckerAkt. 2,73 - +18% - GLTA die drinnen sind!

 
  
    #57
17.07.14 15:42

246516 Postings, 7011 Tage buranMELBOURNE, Australia

 
  
    #58
06.08.14 19:47
Prana Alzheimer's disease Development Program update
22:10 17.07.14

PR Newswire

MELBOURNE, Australia, July 17, 2014

MELBOURNE, Australia, July 17, 2014 /PRNewswire/ -- Prana Biotechnology (NASDAQ: PRAN; ASX: PBT) has today provided an update on its clinical development program for Alzheimer's disease.

Professor Colin Masters, the Florey Institute of Neuroscience and Mental Health, The University of Melbourne, will today include data from Prana's Phase 2 IMAGINE and EURO trials in his presentation at the Alzheimer's Association International Conference in Copenhagen, Denmark.

The presentation is entitled: "How to change and monitor the rates of ABeta amyloid accumulation and cognitive decline in Alzheimer's disease". The presentation can be viewed here: AAIC Panel Presentation_Colin Masters

The IMAGINE trial top-line draft results were released on 31 March 2014. Further sub-analyses of the top line imaging data have been performed, including PiB-PET, MRI and FDG analysis of the effects of a once daily, 250 mg dose of PBT2 over 12 months. IMAGINE enrolled 42 patients, 27 in the PBT2 group and 15 in placebo.

The primary objective of the IMAGINE trial was to explore whether amyloid burden, as measured by PiB-PET would decrease in participants treated with PBT2 relative to placebo. However, in contrast to published literature, the average amyloid burden in the placebo group fell during the trial.

Prana conducted a sub-analysis to better understand the behaviour of the placebo group and what can be learned in the trial about the utility of such exploratory biomarkers for future trials.

In Professor Masters' presentation, he noted that the starting amyloid burden level (baseline) in the PBT2 treated participant group had an important bearing on the decrease of amyloid over time in that participant (p=0.035), whereas there was no such correlation in the placebo group.

Prof Masters further investigated the response of participants with baseline amyloid burden levels above and below the mean for the IMAGINE cohort (SUVR of 2.5). He showed that in the subgroup of PBT2 treated participants with a baseline of SUVR above 2.5, there was a significant decrease in amyloid burden that was not observed in participants on placebo nor PBT2 participants with a SUVR less than 2.5. In summary, whilst the utility of PiB in small trials may be questioned, it was interesting to note the impact of baseline SUVR amyloid burden level on the response of a cohort, for future trial design.

Separately, Prana has confirmed the top line finding that there is a very promising trend towards the preservation of brain volume (as measured by MRI) in PBT2 treated patients compared to placebo patients.

Mechanism of action of PBT2 in AD  

PBT2 prevents formation and toxicity of pathological ABeta species (primarily soluble oligomers) and promotes their clearance. In Professor Masters' presentation he proposes the observed effect upon amyloid burden is due to increased clearance by PBT2 of pools of PIB-detectable non-fibrillar soluble and membrane bound ABeta.

Through its metal chaperone activity, PBT2 activates intracellular signalling pathways which promote neuronal health and plasticity and suppress pathobiological processes including the abnormal phosphorylation of tau. The trend towards reduced hippocampal atrophy seen in the PBT2 treatment group mirrors the Company's preclinical observations and reinforces a similar trend observed in the Reach2HD Huntington's disease study.

"Understanding the limitations of a small trial, the atypical placebo group response, previous clinical findings (the EURO trial), the strong body of peer reviewed science, along with the sub-analyses of IMAGINE, the company remains enthusiastic about the prospects of a large trial statistically powered to demonstrate cognitive benefit," Prof. Masters said.

IMAGINE EXTENSION TRIAL UPDATE  

Patients who completed the full 12-month term of the IMAGINE trial were eligible for participation in an open-label Extension study. All participants in the Extension study receive a 250mg once daily oral dose of PBT2 for an additional 12 months during which PiB-PET and MRI imaging will continue.

Thirty three patients elected to join the Extension trial and of these, 30 remain on the trial. Of those participants, 21 have now been identified as being randomized to the PBT2 treatment arm in the IMAGINE study. Of these, all 21 patients have completed 14 months of PBT2 administration, 20 have completed 18 months of PBT2 administration and nine have completed 21 months of PBT2 administration.

We are very pleased with the continuing safety profile of the drug. The data safety monitoring board has met a further two times and has not expressed any concerns in relation to adverse events.

Contacts:  

Investor Relations  

Rebecca Wilson,? T: +61 3 8866 1216, ?E: rwilson@buchanwe.com.au

Media Relations  

Ben Oliver, ?T: +61 3 8866 1233?, E: boliver@buchanwe.com.au

About Prana Biotechnology Limited  

Prana Biotechnology was established to commercialise research into Alzheimer's disease, Huntington disease and other neurodegenerative and movement disorders. The Company was incorporated in 1997 and listed on the Australian Stock Exchange in March 2000 and listed on NASDAQ in September 2002. Researchers at prominent international institutions including The University of Melbourne, The Mental Health Research Institute (Melbourne) and Massachusetts General Hospital, a teaching hospital of Harvard Medical School, contributed to the discovery of Prana's technology.

Forward Looking Statements  

This press release contains "forward-looking statements" within the meaning of section 27A of the Securities Act of 1933 and section 21E of the Securities Exchange Act of 1934. The Company has tried to identify such forward-looking statements by use of such words as "expects," "intends," "hopes," "anticipates," "believes," "could," "may," "evidences" and "estimates," and other similar expressions, but these words are not the exclusive means of identifying such statements. Such statements include, but are not limited to any statements relating to the Company's drug development program, including, but not limited to the initiation, progress and outcomes of clinical trials of the Company's drug development program, including, but not limited to, PBT2, and any other statements that are not historical facts. Such statements involve risks and uncertainties, including, but not limited to, those risks and uncertainties relating to the difficulties or delays in financing, development, testing, regulatory approval, production and marketing of the Company's drug components, including, but not limited to, PBT2, the ability of the Company to procure additional future sources of financing, unexpected adverse side effects or inadequate therapeutic efficacy of the Company's drug compounds, including, but not limited to, PBT2, that could slow or prevent products coming to market, the uncertainty of patent protection for the Company's intellectual property or trade secrets, including, but not limited to, the intellectual property relating to PBT2, and other risks detailed from time to time in the filings the Company makes with Securities and Exchange Commission including its annual reports on Form 20-F and its reports on Form 6-K. Such statements are based on management's current expectations, but actual results may differ materially due to various factions including those risks and uncertainties mentioned or referred to in this press release. Accordingly, you should not rely on those forward-looking statements as a prediction of actual future results.

SOURCE Prana Biotechnology


Quelle: PR Newswire  

828 Postings, 4864 Tage Toller HechtPremarkt 2,25$

 
  
    #59
21.08.14 14:25
Da kommt vielleicht bald eine Nachricht, weiß jemand vielleicht was anstehen könnte?  

828 Postings, 4864 Tage Toller HechtSorry, vergessen ;-)

 
  
    #60
21.08.14 14:26

805 Postings, 4275 Tage vstreckerWOW!! +45%

 
  
    #61
1
05.09.14 10:50
In FWB +45%

USA yesterday 2,14 , aktuelles Bid/Ask PreMarket 2,67/2,85...

Da müssen noch News kommen....  

1455 Postings, 5716 Tage apfelrückenist der traidinghalt schon

 
  
    #63
05.09.14 14:30
wieder aufgehoben an der asx ?

246516 Postings, 7011 Tage buran19er Nasdaq Ticker im Satz

 
  
    #65
20.09.14 13:51
Datum Erster Hoch Tief Schluss     Stücke Volumen
  19.09.14      2,12      2,24§2,09 2,12 $ 859.793 1,85 M

GrB  

246516 Postings, 7011 Tage buranMario Meierhof 29. September um 21:38,

 
  
    #67
02.11.14 13:20
buran: nur ein börsenboard geführt von www.bundesbank.de 21:18 #1
achte er einfach auf die links
Mit freundlichen Grüssen Mario Meierhof 39517 Lüderitz Gartenstrasse 6
mariomeierhof@web.de
Tel.:039361/96548 Atelier Meierhof 039361/51273 Kuhle
gez MARIO alias buran http://www.ariva.de/…/nur-ein-boersenboard-gefuehrt-von-www…

Deutsche Bundesbank - Startseite
Die Deutsche Bundesbank ist die Zentralbank der Bundesrepublik Deutschland. Zentrales Geschäftsfeld ist die Geldpolitik des Eurosystems.
BUNDESBANK.DE
https://www.facebook.com/mario.meierhof  

246516 Postings, 7011 Tage buranauch ich war im Erziehungsheim lange eine Ewigkeit

 
  
    #68
02.11.14 13:21
buran: auch ich war im Erziehungsheim lange eine Ewigkeit 228.10.14 20:01 #1
Mario Meierhof
29. September um 21:38 ·
buran: nur ein börsenboard geführt von www.bundesbank.de 21:18 #1
achte er einfach auf die links
Mit freundlichen Grüssen Mario Meierhof 39517 Lüderitz Gartenstrasse 6
mariomeierhof@web.de
Tel.:039361/96548 Atelier Meierhof 039361/51273 Kuhle
gez MARIO alias buran http://www.ariva.de/…/nur-ein-boersenboard-gefuehrt-von-www…

Deutsche Bundesbank - Startseite
Die Deutsche Bundesbank ist die Zentralbank der Bundesrepublik Deutschland. Zentrales Geschäftsfeld ist die Geldpolitik des Eurosystems.
BUNDESBANK.DE
https://www.facebook.com/mario.meierhof
http://www.ariva.de/forum/...rziehungsheim-lange-eine-Ewigkeit-510117  

246516 Postings, 7011 Tage buranKontakt.

 
  
    #69
02.11.14 13:22
buran: Kontakt   01.10.14 21:33 #1 Inhalt
Haben Sie Fragen oder Anmerkungen?
Dann nutzen Sie unser Kontaktformular, um uns eine Nachricht zukommen zu lassen.
Als Medienvertreter nutzen Sie bitte die Seite cvd.bundesregierung.de.
Felder mit einem * sind Pflichtfelder und müssen ausgefüllt werden.
Selbstverständlich beachten wir die Vorschriften des Datenschutzes.
Hier geht es zur Datenschutzerklärung.

Betreff * Hallo ,vielleicht sowas mal unterbinden wäre nett


Ihre Anregungen und Fragen (max. 10.000 Zeichen) *noch 9663 Zeichen nur ein börsenboard geführt von www.bundesbank.de
achte er einfach auf die links

Mit freundlichen Grüssen Mario Meierhof 39517 Lüderitz Gartenstrasse 6
mariomeierhof@web.de
Tel.:039361/96548 Atelier Meierhof 039361/51273 Kuhle

gez MARIO alias buran http://www.ariva.de/forum/...rd-gefuehrt-von-www-bundesbank-de-508523


Vor- und Zuname * Mario Meierhof

E-Mail *mariomeierhof@web.de


Straße und Hausnummer Gartenstrasse 6

Postleitzahl 39517

Ort Lüderitz

* Pflichtangabe
https://www.bundesregierung.de/Webs/Breg/DE/.../kontaktform_node.html

Mit freundlichen Grüssen Mario Meierhof alias buran
http://www.ariva.de/forum/Kontakt-508620?new_pnr=18779196#bottom  

805 Postings, 4275 Tage vstreckerPRAN Morgen Zahlen

 
  
    #70
12.11.14 21:09
Irgendwie sieht das für Morgen ziemlich gut aus.

Ich bleib mit 6.000 Stück drinnen.

GLTA  

805 Postings, 4275 Tage vstreckerInteressant

 
  
    #71
18.11.14 11:11

246516 Postings, 7011 Tage buranPräsenzbörse

 
  
    #72
30.12.14 17:53
Die Präsenzbörse ist die klassische Form des Börsenhandels. Hierbei finden die Geschäftsabschlüsse auf dem Börsenparkett zwischen den Händlern im persönlichen Kontakt statt.  http://www.ariva.de/extras/lexikon.m?begriff=Praesenzboerse
 

246516 Postings, 7011 Tage buran#72 Gegenteil:

 
  
    #73
30.12.14 17:54

246516 Postings, 7011 Tage buranü 2,2 Millionnas aufen Ticker Amboss gedroschen RT

 
  
    #74
13.02.15 17:52

1768 Postings, 4002 Tage GurkenheiniMontag

 
  
    #75
15.02.15 10:50
Gehts wieder rauf.
Solche Kurse muss man einfach zum Kauf nutzen.Prana war schon mal 1 Euro Wert danach auf ueber 10 Euro gestiegen,jetz wieder um 1 Euro wert.Hier wird der Kurs in ein paar Monate einige hundert Prozent machen.Schaut such den Langfrist Chart an.
Ich bin dabei,so ne Chance werde ich nutzen.  

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