Amarantus BioSciences in aller Munde
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Eröffnet am: | 06.11.12 12:06 | von: Balu4u | Anzahl Beiträge: | 31 |
Neuester Beitrag: | 18.12.12 08:29 | von: madeinhell | Leser gesamt: | 10.141 |
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Wird hier gerade hoch disktutiert. Leider gibt es bei der Aktie direkt keinen Thread. Daher mach ich eben mal einen auf.
Über Amarantus: http://www.amarantus.com/
http://investorshub.advfn.com/Amarantus-BioSciences-Inc-AMBS-21711/
http://www.hotstocked.com/article/40292/...nc-otc-ambs-pump-goes.html
Interessanter Abschnitt: Yesterday OTC biotech company Amarantus Biosciences, Inc. (OTC:AMBS, AMBS message board) almost doubled in value, driven by pump emails and hype. The stock gained 94% and reached $0.054 at the closing bell.
The company nearly repeated its previous run of over 46 million shares traded as enthusiastic traders bought the stock on the promise pumpers and press releases touted. The story around AMBS so far is a very large cloud of optimism that contains a lot of uncertain promises for the future and not much else.
The company is being continuously pumped through email campaigns. The emails and hype are focused on the intentions AMBS has to 'pursue' therapeutic indications that 'could' lead to FDA designation of their protein as a rare-disease drug. The problem is, AMBS are nowhere near this stage in their product development. A recently published independent study reported, among other things, that the next stage of the drug testing and development is moving on to 'primate model' testing. That may give eager investors some idea how close the ultimate goal is.
zu Ø 0,024. das ding wir die nächsten wochen sehr hoch fliegen. am wochenende steht auch ein termin zur präsentation in us an. die firma hat ein blockbustermedikament welches vielen leuten helfen könnte, schon alleine das ist mir mein geld wert.
es werden hier noch weitere große investoren kommen, wenn nicht vorher ein buyout stattfindet.
in us gestern auf th und +20% geschlossen! das sollte heute den shortkessel zum kochen bringen. denn hier sind noch einige naked ;)
bitte DIESEN newsflow und den inhalt dieser doch vielen Meldungen beachten. eine der aktien die man wohl so schnell nicht wieder findet. m.M.n riesen chance hier.
http://www.finanznachrichten.de/...tien/amarantus-biosciences-inc.htm
Und hier RT US für 15.30
AMBS is clearly setting itself up for a partnership with a larger pharma company. Remember what Rubinfeld said:
"I have reviewed a great number of technologies in my 45 year career in the biopharmaceutical field, and I believe that MANF could be one of the biggest successes that I have ever seen. The fundamental scientific premise of reducing protein misfolding is basic, yet very profound. The data, while early, demonstrates very clearly at the cellular level and in animals that MANF reduces apoptosis, improves cellular function, and restores behavioural deficits in a number of disease models, including Parkinson's, Stroke, Myocardial Infarction and Traumatic Brain Injury. These are all indications with very large markets and clear unmet medical need. I believe that if we are able to further de-risk MANF with positive toxicology studies and early clinical data, the Company's new orphan drug strategy could get MANF to market rather expeditiously. MANF has the commercial potential to become a blockbuster drug."
The most recent advisors added to the board are:
*Dr Joseph Rubinfeld - co-founder of Amgen
*Clinton Allen - Bristol Myers Squibb, Director of Product Development and Commercialization, Director of In-licensing and Business Development
*Dr. Robert Zimmerman - Vice President of Biotechnology Research at Bayer Corporation
Keep in mind what Mr. Zimmerman said:
"I have been involved with Amarantus formally and informally for the past three years supporting the founders as they work tirelessly to advance MANF to a stage where it has real commercial potential," said Robert J. Zimmerman, SD. "While that effort has been centered on Parkinson's disease, I believe additional opportunities exist to diversify this therapeutic candidate. Ischemia/reperfusion, cardiovascular disease, stroke, traumatic brain injury, diabetes and potentially other disease conditions appear to be impacted by MANF based upon preclinical studies and the literature."
They stated in their press release that "Dr. Zimmerman will also assist in the procurement of relationships with top-tier vendors".
Additionally, they are pursuing an Orphan Drug strategy with MANF which many investors seem to have forgotten about.
And don't forget their patents on MANF which don't expire until 2031:
“Today’s announcement is transformational for Amarantus from a scientific data standpoint,” said Gerald E. Commissiong, President & CEO of Amarantus. “Despite the many clear scientific
advantages we believe MANF possesses over GDNF, most notably impacting protein folding and modulating toxic calcium levels, the Company had previously been unable to point to a definitive behavioural animal model data to show improved benefit of MANF over GDNF in the Parkinson’s disease indication. The data we now have validates the approach we have been taking over the last several years, and we believe that it will allow us to attract the interest of investment firms and potential partners who will be able to now characterize the substantial opportunity our technology represents. We believe that we are well positioned to leverage the MANF opportunity for Amarantus shareholders and Parkinson’s patients because of the expansive intellectual property (IP) portfolio the Company owns, including composition of matter patents in the US and Europe, use patents worldwide and provisional delivery dosing patents that have been filed based on today’s data, extending marketing exclusivity for MANF through 2031. This IP position may make MANF more attractive to a potential partner than other neurotrophic factors in development that do not have the same patent runway.”"
Das sollte den Kurs doch wieder in Fahrt bringen!
http://ih.advfn.com/...nmona&article=55195222&symbol=…
Amarantus BioSciences Announces Positive Data for MANF in Delivery Diffusion Animal Model of Parkinson's Disease |
SUNNYVALE, Calif., Nov. 27, 2012 /PRNewswire/ -- Amarantus BioSciences, Inc. (OTCQB: AMBS), a biotechnology company developing new disease-modifying treatments and diagnostics for Parkinson's disease and Traumatic Brain Injury centered on its proprietary anti-apoptosis therapeutic protein MANF, today announced that the Company has successfully completed experiments demonstrating that MANF has an excellent diffusion profile in the striatum of rat brains. The striatum is located in the brain, and is partially responsible for proper movement as part of the basal ganglia network. The striatum becomes severely compromised in Parkinson's disease due to neurite retraction from dopaminergic neurons located in the substantia nigra. The data generated in this study show that when compared to GDNF, a neurotrophic factor currently in a Phase 2 clinical trial for Parkinson's disease, MANF had a significantly higher volume of distribution when delivered to the striatum. These results are part of on-going animal studies to determine the best localization of delivering MANF to the brain in Parkinson's disease human clinical studies. "The data obtained in this study provide strong evidence that volume distribution from the site of delivery in the brain is unlikely to be an impediment to MANF's clinical progress," said John W. Commissiong, PhD, Chief Scientist at Amarantus. "Volume distribution from the site of delivery appears to have been one of the key shortfalls of previous clinical trials of neurotrophic factors in Parkinson's disease. These results provide a higher degree of certainty that MANF is unlikely to fail in the clinic due to inadequate diffusion volumes." In studies conducted by Dr. Steven Gill's laboratory at the University of Bristol, MANF and GDNF were injected directly into the striatum of separate groups of rats in order to mimic as closely as possible the treatment setting in humans. Seven days following delivery under best available conditions, MANF's diffusion volume was ~30% greater than GDNF's. "The results of this study provide further support to MANF's real-world potential as a disease-modifying treatment for Parkinson's disease, and potentially other brain disorders," said Gerald E. Commissiong, President and CEO of Amarantus. "Diffusion from the site of delivery in the brain has been a key problem plaguing the development of other neurotrophic factors for Parkinson's disease for some time. We now have further evidence that MANF appears to have added biological advantages over other neurotrophic factors in development, and the Company intends to leverage these results as we continue to advance our Parkinson's program, as well as explore additional applications for MANF in orphan disease applications. The Company is currently evaluating various delivery technologies to clinically deliver MANF to the brain in Parkinson's disease, and will update the market of its intentions as definitive agreements emerge." Large pharmaceutical companies have shown significant interest in neurotrophic factors for Parkinson's disease for over two decades. In 1993, Amgen acquired Synergen for $262 million shortly after Synergen successfully completed studies using GDNF as a protein therapeutic in animal models of Parkinson's disease. In 2007, Genzyme entered into a $150 million partnership with Ceregene to gain access to ex-U.S. marketing rights Neurturin after Ceregene successfully completed a Phase 1 clinical study demonstrating safety for Neurturin as a gene therapy product. Amarantus owns composition of matter and method of use patents for MANF, including claims for use of MANF as a protein therapy, gene therapy and as an adjuvant within the context of cell therapy. About Amarantus BioSciences, Inc. Amarantus BioSciences, Inc. is a development-stage biotechnology company founded in January 2008. The Company has a focus on developing certain biologics surrounding the intellectual property and proprietary technologies it owns to treat and/or diagnose Parkinson's disease, Traumatic Brain Injury and other human diseases. The Company owns the intellectual property rights to a therapeutic protein known as Mesencephalic-Astrocyte-derived Neurotrophic Factor ("MANF") and is developing MANF-based products as treatments for brain disorders. The Company also is a Founding Member of the Coalition for Concussion Treatment (#C4CT), a movement initiated in collaboration with Brewer Sports International seeking to raise awareness of new treatments in development for concussions and nervous-system disorders. For further information please visit www.Amarantus.com. Forward Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements include, but are not limited to, statements about the possible benefits of MANF therapeutic applications and/or advantages presented by Amarantus' PhenoGuard technology, as well as statements about expectations, plans and prospects of the development of Amarantus' new product candidates. These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including the risks that the anticipated benefits of the therapeutic drug candidates or discovery platforms, as well as the risks, uncertainties and assumptions relating to the development of Amarantus' new product candidates, including those identified under "Risk Factors" in Amarantus' most recently filed Annual Report on Form 10-K and Quarterly Report on Form 10-Q and in other filings Amarantus periodically makes with the SEC. Actual results may differ materially from those contemplated by these forward-looking statements Amarantus does not undertake to update any of these forward-looking statements to reflect a change in its views or events or circumstances that occur after the date of this presentation. |
Amarantus BioSciences Announces Positive Data for MANF in Delivery Diffusion Animal Model of Parkinson's Disease |
Amarantus Biosci (OTCBB:AMBS) |
http://www.thechairmansblog.com/...ury-cardiac-ischemia-and-more.html
http://www.boerse-berlin.de/data/publications/Publication_38570.pdf